BIOSECURITY COMPLIANCE • RESEARCH USE ONLY

Terms of Service & Biosecurity Compliance

Last Updated: September 2026 • Tresslers Group Sovereign Infrastructure

Research Use Only (RUO) Notice: Logos is an in-browser bioinformatics utility designed strictly for academic, educational, and preclinical laboratory research. Logos is not certified, intended, or approved for clinical diagnosis, patient treatment, medical decisions, or therapeutic manufacturing. Always verify codon predictions, restriction site profiles, and open reading frames in laboratory test assays before physical gene synthesis.

1. Strict Biosecurity & Select-Agent Prohibition

In accordance with international biosecurity norms, United States Federal Select Agent Program regulations (42 CFR Part 73, 7 CFR Part 331, 9 CFR Part 121), and the Biological Weapons Convention (BWC), users agree that they will not use Logos to model, design, optimize, or prepare sequences intended for:

Viruses, bacteria, fungi, or toxins classified as Tier 1 Select Agents or high-consequence dual-use biological agents.
Biological toxins listed under the Chemical Weapons Convention or Australia Group export control schedules (e.g., Ricin, Botulinum neurotoxin, Staphylococcal enterotoxin B, T-2 toxin).
Gain-of-function variants intended to confer enhanced airborne transmissibility, extreme lethality, or resistance to licensed therapeutics or vaccines against high-consequence human pathogens.
Any vector or organism intended for hostile deployment, bioterrorism, or proliferation of biological weapons.

2. Synthesis Screening Responsibility

While Logos assists in optimizing synonymous codon choices, the end user and ordering investigator maintain sole legal and operational responsibility for submitting constructs to certified commercial gene synthesis providers (e.g., Twist Bioscience, Integrated DNA Technologies, GenScript) that execute rigorous customer verification and automated sequence screening per the Guidance for Providers of Synthetic Double-Stranded DNA.

3. Intellectual Property and Open Computational Tools

Sequences submitted into the Logos in-browser workbench remain the exclusive intellectual property of the user. Logos does not claim any ownership, licensing, patent rights, or royalty interest in sequences, constructs, or downstream proteins designed using this tool.

4. Warranty Disclaimer & Limitation of Liability

Logos and its underlying algorithms (including Nussinov RNA folding, CAI modeling, and simulated annealing heuristics) are provided on an "as-is" and "as-available" basis without warranty of any kind, express or implied. Tresslers Group and its contributors do not warrant that computational predictions will guarantee specific in-vitro or in-vivo protein expression yields, solubility, or catalytic activity.

5. Inquiries and Institutional Licensing

For enterprise deployment, custom host calibration, or institutional bioinformatics integration, contact intelligence@tresslersgroup.com or visit tresslersgroup.com/contact.